Neuron-specific effects of
microtubule dynamics


Neurons display an amazing diversity of shapes, sizes and activities. Underlying neuron structure and function is the microtubule cytoskeleton. Microtubules can be stable or highly dynamic, undergoing bouts of growth and shrinkage. We want to know how microtubule dynamics are differentially regulated to control the shape and function
​of diverse neuron types.

Neuronal FedEx:
Transporting cargo to
​axons & dendrites

​Neurons are exquisite examples of polarized cells: dendrites, with their tree-like arbors, receive signals, and slender axons reach over long distances to transmit signals. We are investigating how molecular motors ​(dynein and kinesin) pick-up cargos and navigate microtubule highways to deliver organelles, vesicles, and proteins to the right place, enabling neurons to function properly.

Localization of
​Pain-sensing Ion Channels

​​
​Sensory neurons enable us to perceive the surrounding environment. The localization of ion channels to sensory neuron dendrites is critical to the detection of external stimuli. We are elucidating the pathways by which pain-sensing ion channels localize to the dendritic membrane. We are also exploring how ion channel levels are regulated in dendrites to tune sensory perception and behavior.